Altered microRNA expression in human heart disease Running Title: Altered miRNA expression in human heart disease

Department of Cardiology, Children’s Hospital Boston, and Department of Genetics, Harvard Medical School, Boston, Massachusetts Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, and the Broad Institute of Harvard and MIT, Cambridge, Massachusetts Department of Cardiology and Pneumology, Georg August University, Göttingen, Germany Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts Department of Medicine, Children’s Hospital Boston, Boston, MA, and Howard Hughes Medical Institute, Chevy Chase, Maryland